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Bryan Johnson Supplement Stack
Biohacker, Entrepreneur & Blueprint Founder
Bryan Johnson is the founder of Kernel (brain-computer interface) and Blueprint, a protocol designed to reverse biological aging. He spends approximately $2M per year on his 'Don't Die' mission, measuring hundreds of biomarkers monthly and optimizing every aspect of his biology. His Blueprint protocol is publicly available.
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Medische disclaimer: De informatie op deze pagina is uitsluitend bedoeld voor educatieve doeleinden en vormt geen medisch advies, diagnose of behandeling. Raadpleeg altijd een arts of gekwalificeerde zorgverlener voordat je supplementen gebruikt of je leefstijl aanpast.
Supplementation Philosophy
Johnson's philosophy is radical data-driven optimization. He treats his body as a system to be optimized using measurement, not intuition. His Blueprint protocol is based on the principle that algorithms (data + science) should make health decisions, not human willpower or preference. He eats the same meals every day, sleeps at the same time, and takes 100+ supplements.
Watch: Bryan Johnson on Supplements
Complete Supplement Stack (10 supplements)
Acarbose
200mg with meals (prescription)
Slows carbohydrate absorption to reduce post-meal glucose spikes. Johnson uses it to minimize glycemic variability. Prescription only in most countries.
Metformin
1500mg daily (prescription)
Activates AMPK, mimics calorie restriction effects. Johnson takes it for longevity despite controversy about exercise adaptation blunting.
Omega-3 (EPA/DHA)
3.3g EPA + 2.2g DHA daily
Very high dose omega-3 for cardiovascular and brain health. Johnson takes one of the highest doses publicly reported.
Vitamin D3/K2
2000 IU D3 + K2
Maintains optimal vitamin D levels. Johnson tests regularly and adjusts dose based on blood levels.
NMN
500mg daily
NAD+ precursor for cellular energy and DNA repair. Part of Johnson's anti-aging protocol targeting the hallmarks of aging.
Rapamycin
13mg weekly (prescription)
mTOR inhibitor with strong longevity evidence in animal models. Johnson takes one of the highest doses of any public figure. Prescription only.
Lycopene
10mg daily
Powerful antioxidant from tomatoes. Johnson takes it for cardiovascular and prostate health. Available OTC.
Creatine Monohydrate
5g daily
For muscle preservation and cognitive function. Johnson prioritizes muscle mass as a longevity biomarker.
Fisetin
200mg daily
Senolytic flavonoid that may clear senescent cells. Johnson takes it as part of his anti-aging protocol. Emerging evidence.
Taurine
2g daily
A 2023 Science paper showed taurine levels decline with age and supplementation extended lifespan in mice. Johnson added it after this publication.